Most other breeds have both wild type and dilute alleles. Some cat breeds are fixed for the wild type, such as Egyptian Mau and Singapura, while others are fixed for dilute, such as Chartreux, Korat, and Russian Blue. Black pigment is diluted to gray ("blue" is the term used by cat breeders), and red is diluted to cream. Dilute is an an autosomal dominant trait, which means that two copies of the dilute allele are needed to produce the phenotype. Dilute is caused by the deletion of a single base (c.83delT) resulting in disruption of the MLPH protein product. Note: Overall appearance of the cat's coat also depends on expression of and complex interactions with other genes.Ī mutation in Melanophilin (MLPH) causes clumping and uneven distribution of pigment granules in the hair shaft, producing dilution of all coat colors.
Matings with other d/d genotype cats are expected to produce all dilute offspring. Cats with d/d genotype will display dilute coat color(s) and will transmit this dilute variant to all of their offspring.Matings between two carriers of dilute are predicted to produce 25% dilute kittens. Cats with D/d genotype will be full-colored and are carriers of this dilute variant.Cats with D/D genotype will be full-colored and cannot transmit this dilute variant to their offspring.
For example, black pigment is diluted to gray and red is diluted to cream.Īlleles: D = Wild type (full color), d = Diluteīreeds appropriate for testing: Many breeds Phenotype: Pigment granules in the hair shaft are clumped and unevenly distributed, producing dilution of coat colors. Red (left) Red diluted to cream (second from left) Black (second from right) Black diluted to gray (right)
DILUTE BLACK TABBY FULL
British Shorthair kittens showing full colors and their respective dilutions.
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